Everything about Peter Walter totally explained
Peter Walter is a German-American
molecular biologist and
biochemist. He earned a B.S. degree in
chemistry from the
Free University of Berlin, an M.S. degree in
organic chemistry from
Vanderbilt University, and a Ph.D. in
biochemistry from the
Rockefeller University. He is currently Professor and Chairman of the Department of
Biochemistry and
Biophysics at the
University of California, San Francisco (UCSF).
Peter Walter's laboratory at UCSF is engaged in studying
protein folding and
protein targeting, focusing on the
signal recognition particle (which he identified and characterized some years ago as a graduate student with
Günter Blobel at the Rockefeller). Peter Walter has discovered a
feedback loop within cells called the unfolded protein response. Cells need the right amount of
endoplasmic reticulum (ER) to properly fold new proteins. If there's too little ER, misfolded proteins accumulate, triggering a signaling pathway between the ER and the nucleus that produces more ER to increase the capacity with which the proteins can be properly folded. If this feedback loop doesn't work and misfolded proteins accumulate inside the ER, the cell commits suicide. Walter's lab has identified three
genes centrally involved in the unfolded protein response.
Peter Walter is an Investigator of the
Howard Hughes Medical Institute (External Link
) and a member of the
National Academy of Sciences.
(External Link)
Professor Walter is a co-author of
Molecular Biology of the Cell, now in its fourth edition.
Further Information
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